Mechanisms of carcinogenic activity triggered by lysine-specific demethylase 1A

Mechanisms of carcinogenic activity triggered by lysine-specific demethylase 1A

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Epigenetics has emerged as a prime focus area in the field of cancer research.Lysine-specific demethylase 1A (LSD1), the first discovered histone demethylase, is mainly responsible for catalysing demethylation of histone 3 lysine 4 (H3K4) and H3K9 to activate or inhibit gene transcription.LSD1 is abnormally expressed in Ball - Shoes Metal - Womens various cancers and participates in cancer proliferation, apoptosis, metastasis, invasion, drug resistance and other processes by interacting with regulatory factors.Therefore, it may serve as a potential therapeutic target for Sewing Machine Accessories cancer.

This review summarises the major oncogenic mechanisms mediated by LSD1 and provides a reference for developing novel and efficient anticancer strategies targeting LSD1.